MG-516 is primarily utilized in research settings for its role as a selective inhibitor of the enzyme soluble epoxide hydrolase (sEH). This enzyme is involved in the metabolism of epoxy fatty acids, which play a significant role in inflammation and cardiovascular health. By inhibiting sEH, MG-516 helps in studying the pathways related to inflammatory responses, pain management, and vascular function. It is particularly valuable in preclinical studies aimed at understanding and developing treatments for conditions such as hypertension, diabetes, and chronic pain. Additionally, MG-516 is used to explore the potential therapeutic benefits of targeting sEH in various disease models, providing insights into novel pharmacological interventions.