SJB2-043 is primarily used in research settings as a selective inhibitor of the enzyme soluble epoxide hydrolase (sEH). By inhibiting sEH, it helps stabilize endogenous epoxyeicosatrienoic acids (EETs), which have anti-inflammatory, analgesic, and vasodilatory effects. This makes SJB2-043 a valuable tool in studying inflammatory pain, neuropathic pain, and cardiovascular conditions. It has shown efficacy in preclinical models for reducing pain hypersensitivity without significant central nervous system side effects, suggesting potential for developing non-opioid pain therapeutics. Its use is currently restricted to laboratory and experimental studies to explore pathways related to pain modulation and inflammation control.