Wang Resin is widely used in solid-phase peptide synthesis (SPPS) as a solid support material. Its primary application is to anchor the growing peptide chain during the synthesis process, allowing for sequential addition of amino acids. The resin is particularly valued for its stability under acidic conditions, making it suitable for Fmoc (fluorenylmethyloxycarbonyl) chemistry, a common method in peptide synthesis. After the peptide is fully synthesized, it can be cleaved from the resin using trifluoroacetic acid (TFA), yielding the final product. Wang Resin is also employed in the synthesis of small molecules and other organic compounds where a stable, acid-labile linker is required. Its ease of use and compatibility with various reagents make it a popular choice in combinatorial chemistry and drug discovery research.