Sieber Amide Resin is widely used in solid-phase peptide synthesis (SPPS) as a versatile support material. Its application is particularly valuable in the synthesis of peptide amides, as it allows for the efficient cleavage of the final product under mild acidic conditions, preserving sensitive functional groups. The resin is compatible with Fmoc (9-fluorenylmethoxycarbonyl) chemistry, making it suitable for the stepwise assembly of peptides. Additionally, it is employed in the preparation of peptide libraries for drug discovery and biochemical research, offering high loading capacity and stability during synthesis. Its use extends to the production of modified peptides and peptidomimetics, where precise control over the final product is essential.