A-803467 is a potent and selective blocker of the voltage-gated sodium channel Nav1.8, which is primarily expressed in peripheral sensory neurons. Due to this selectivity, it is widely used in research to study pain pathways, especially those involved in neuropathic and inflammatory pain. It has shown efficacy in reducing pain signals in preclinical models without affecting motor function or other major sodium channel subtypes, making it a valuable tool for investigating new analgesic targets. Its application is mainly restricted to laboratory and pharmacological studies, aiding in the development of novel pain management therapies.