Auraptenol is a natural compound from the coumarin and flavonoid groups, commonly used as a reference standard in analyzing plant-derived natural substances. It is employed in biochemical and pharmaceutical research, particularly for its antioxidant and anti-inflammatory properties. In dermatological studies, it shows skin-lightening effects by inhibiting melanin production via key pigmentation enzymes, making it a candidate for treating hyperpigmentation like melasma and age spots. It also demonstrates antimicrobial activity for potential topical skin infection treatments and preliminary inhibition of certain cancer cell growth, including skin and breast cancer, in in vitro and animal models. These properties support its use in cosmetic formulations to reduce skin aging and UV damage. Ongoing research assesses its stability, penetration in skincare products, and clinical potential, though it is not yet clinically applied.