SIRT6-IN-1 is a selective inhibitor of the SIRT6 enzyme, which plays a key role in DNA repair, metabolism, and aging processes. It is primarily used in research settings to study the biological functions of SIRT6. By inhibiting SIRT6 activity, this compound helps scientists investigate pathways related to cellular aging, glucose metabolism, and genomic stability. It has shown potential in enhancing the effects of chemotherapy in certain cancer models by impairing DNA repair mechanisms in tumor cells. Additionally, SIRT6-IN-1 is used to explore metabolic diseases and age-related conditions, offering insights into new therapeutic strategies. Its application remains confined to preclinical research, particularly in cell culture and animal models.