Acetyltrimethylsilane is primarily used in organic synthesis as a reagent for introducing the trimethylsilyl group into molecules. This group serves as a protecting group for alcohols and other functional groups, enhancing stability during chemical reactions. It is also employed in the preparation of silyl enol ethers, which are intermediates in various organic transformations, including aldol reactions and Michael additions. Additionally, it finds application in the modification of surfaces and materials, where it imparts hydrophobic properties. Its use extends to the synthesis of silicon-containing polymers and in the production of specialty chemicals for the pharmaceutical and agrochemical industries.