3,5-Bis(trifluoromethyl)phenyldimethylsilane is an organosilicon reagent used in organic synthesis, particularly for introducing trifluoromethyl-substituted aryl groups in the preparation of compounds for pharmaceuticals and agrochemicals. The electron-withdrawing trifluoromethyl groups enhance stability and lipophilicity, making it valuable in the development of bioactive molecules. It is commonly employed in cross-coupling reactions, such as Hiyama-Denmark coupling, and as an intermediate in the synthesis of functional materials, including liquid crystals and organic semiconductors. Additionally, it finds use in modifying silica surfaces for chromatographic supports due to its strong hydrophobic interactions.