tert-Butyldimethyl(pent-4-yn-1-yloxy)silane is the tert-butyldimethylsilyl (TBDMS) protected form of pent-4-yn-1-ol, serving as a versatile building block in organic synthesis. The TBDMS group protects the hydroxyl functionality, allowing selective manipulation of the terminal alkyne or other reactive sites under various reaction conditions. It offers stability and steric hindrance to minimize side reactions, with deprotection achievable selectively using fluoride ions or acidic conditions. This compound is widely used in multi-step syntheses of complex molecules, including natural products, pharmaceuticals, agrochemical intermediates, and specialty materials.