tert-Butyldimethyl(prop-2-ynyloxy)silane is a protected form of propargyl alcohol, where the hydroxyl group is shielded by a tert-butyldimethylsilyl (TBDMS) protecting group. This compound serves as a versatile building block and intermediate in organic synthesis, enabling the introduction of the propargyl (prop-2-ynyl) functionality into complex molecules without interference from the alcohol. It is particularly useful in multi-step reactions involving terminal alkynes, such as Sonogashira couplings or click chemistry (e.g., azide-alkyne cycloadditions). The TBDMS group provides stability during synthesis and can be selectively removed under mild acidic or fluoride conditions. Applications include the preparation of pharmaceuticals, agrochemicals, peptides, carbohydrates, and functionalized polymers or biomolecules, where precise control over functional group reactivity is essential.