Ethoxytriphenylsilane is widely used in the field of organic synthesis as a protecting group for alcohols. It reacts with hydroxyl groups to form stable silyl ethers, which can protect the alcohol functionality during complex chemical reactions. This is particularly useful in multi-step synthesis processes where selective protection and deprotection are required.

In materials science, it serves as a precursor for the preparation of silicone-based polymers and resins. Its ability to form siloxane bonds makes it valuable in the development of coatings, adhesives, and sealants with enhanced thermal stability and water resistance.

Additionally, it is employed in the modification of surfaces, such as glass or silica, to impart hydrophobic properties. This application is crucial in creating water-repellent coatings for various industrial and consumer products.

In the pharmaceutical industry, ethoxytriphenylsilane is utilized in the synthesis of drug intermediates, where it helps in achieving high selectivity and yield in critical reaction steps.