Iodotrimethylsilane is widely used in organic synthesis as a reagent for introducing trimethylsilyl groups into molecules. It is particularly effective in protecting alcohols and phenols by converting them into their corresponding trimethylsilyl ethers, which are stable under various reaction conditions. This protection allows for selective reactions to be carried out on other functional groups within the molecule. Additionally, it is employed in the cleavage of ethers, especially methyl ethers, to yield the corresponding alcohols. Its ability to act as a desilylating agent also makes it valuable in the deprotection of silyl-protected compounds, facilitating the regeneration of the original functional groups. In peptide synthesis, it is used to remove protecting groups from amino acids, enabling the construction of complex peptide chains. Its versatility and reactivity make it a crucial tool in the development of pharmaceuticals, agrochemicals, and fine chemicals.