Trimethylsilylbenzenesulfonate is primarily used as a reagent in organic synthesis, particularly in the protection of hydroxyl groups. It acts as a silylating agent, converting alcohols into their corresponding trimethylsilyl ethers, which are more stable and less reactive under certain conditions. This protection is crucial in multi-step synthetic processes where specific functional groups need to be preserved while other reactions are carried out. Additionally, it is employed in the preparation of sulfonate esters, which are intermediates in the synthesis of various pharmaceuticals and agrochemicals. Its role in facilitating selective reactions makes it valuable in the development of complex organic molecules.