2-(Trimethylsilyl)ethoxymethyl chloride (SEMCl) is widely used in organic synthesis as a protecting group for alcohols, amines, and other functional groups. Its primary application lies in the protection of hydroxyl groups during complex chemical reactions, particularly in the synthesis of natural products, pharmaceuticals, and peptides. SEMCl forms stable SEM ethers, which are resistant to acidic and basic conditions, allowing selective deprotection without affecting other sensitive groups in the molecule. It is also employed in carbohydrate chemistry to protect sugar hydroxyls and in nucleotide synthesis to safeguard reactive sites. Additionally, SEMCl is utilized in solid-phase peptide synthesis to prevent unwanted side reactions. Its versatility and stability make it a valuable tool in multi-step synthetic processes.