Tris(trimethylsilyl) borate is primarily used as a reagent in organic synthesis, particularly in the protection of hydroxyl groups. Its ability to form stable silyl ethers makes it valuable in the preparation of complex molecules where selective protection and deprotection of functional groups are required. It is also employed in the modification of surfaces, especially in the field of materials science, where it can enhance the hydrophobic properties of materials. Additionally, it finds application in the synthesis of boron-containing compounds, which are useful in various chemical processes and as intermediates in the production of pharmaceuticals and agrochemicals.