5-(((tert-Butyldimethylsilyl)oxy)methyl)-5-phenylimidazolidine-2, 4-dione
95%
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This compound, 5-(((tert-Butyldimethylsilyl)oxy)methyl)-5-phenylimidazolidine-2,4-dione, serves as a key protected intermediate in organic synthesis, especially for pharmaceutical applications. The imidazolidine-2,4-dione (hydantoin) core features a phenyl group and a hydroxymethyl substituent at the 5-position, where the hydroxyl is protected by the tert-butyldimethylsilyl (TBDMS) group. This silyl ether protection shields the hydroxyl from unwanted reactions during multi-step syntheses, enabling selective transformations of other functional groups. The TBDMS protecting group is stable under a wide range of conditions but can be selectively removed using mild reagents like tetrabutylammonium fluoride (TBAF), restoring the free hydroxyl without affecting the rest of the molecule. Such protected intermediates are essential in the development of complex drugs, agrochemicals, and fine chemicals requiring precise control over reactivity.
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