(3-Bromophenoxy)(tert-butyl)dimethylsilane
98%
Reagent
Code: #151020
CAS Number
65423-56-5
blur_circular Chemical Specifications
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Molecular Information
Weight
287.27 g/mol
Formula
C₁₂H₁₉BrOSi
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Registry Numbers
MDL Number
MFCD01318106
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Storage & Handling
Density
1.16 g/cm3(Predicted)
Storage
2-8°C, inert atmosphere
description Product Description
(3-Bromophenoxy)(tert-butyl)dimethylsilane is the tert-butyldimethylsilyl (TBDMS)-protected derivative of 3-bromophenol. The silyl ether serves as a protecting group for the phenolic hydroxyl, enabling selective reactions at the aryl bromide position, such as palladium-catalyzed cross-coupling (e.g., Suzuki-Miyaura, Sonogashira). This stability under basic and neutral conditions, with deprotection possible under mild acidic conditions, makes it valuable in multi-step organic synthesis, particularly for pharmaceuticals, agrochemicals, and advanced materials. The bulky TBDMS group provides steric hindrance, minimizing unwanted side reactions during assembly of complex molecules.
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