tert-Butyldiphenyl(prop-2-yn-1-yloxy)silane

95%

Reagent Code: #150798
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CAS Number 88159-06-2

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 294.47 g/mol
Formula C₁₉H₂₂OSi
badge Registry Numbers
MDL Number MFCD31555366
thermostat Physical Properties
Melting Point 58-60 °C
Boiling Point 338.3±34.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.00±0.1 g/cm3(Predicted)
Storage 2-8°C

description Product Description

This compound, tert-butyldiphenyl(prop-2-yn-1-yloxy)silane, is the tert-butyldiphenylsilyl (TBDPS)-protected form of propargyl alcohol. It serves as a key building block in organic synthesis, allowing the terminal alkyne to undergo selective reactions (e.g., couplings, cycloadditions) without interference from the hydroxyl group. The bulky TBDPS protecting group provides excellent stability in basic, neutral, and mildly acidic conditions, and can be removed orthogonally using fluoride ions (e.g., TBAF) in the presence of other functional groups. This reagent is particularly valuable for constructing polyfunctional molecules, such as pharmaceuticals, natural products, and materials, where precise control over the propargyl functionality is essential. The steric bulk of TBDPS also minimizes side reactions during multi-step sequences.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿10,300.00
inventory 250mg
10-20 days ฿18,720.00
inventory 1g
10-20 days ฿37,440.00

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