tert-Butyldimethylsilyl R-(-)-glycidyl ether
98%
Reagent
Code: #143563
Alias
(R)-t-tert-butyldimethylsilyl glycidyl ether
CAS Number
124150-87-4
blur_circular Chemical Specifications
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Molecular Information
Weight
188.34 g/mol
Formula
C₉H₂₀O₂Si
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Registry Numbers
MDL Number
MFCD01862147
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Physical Properties
Boiling Point
195-199 °C/760 mmHg
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Storage & Handling
Density
0.870 g/mL at 25 °C
Storage
Room temperature
description Product Description
Used as a chiral protecting group reagent in organic synthesis, particularly in the pharmaceutical industry for the selective protection of hydroxyl groups in complex molecule assembly. Its epoxide ring allows for regioselective ring-opening reactions, enabling controlled functionalization in multi-step syntheses of bioactive compounds. Commonly employed in the preparation of prostaglandins, antibiotics, and other stereochemically defined intermediates. The tert-butyldimethylsilyl (TBS) group provides stability under a variety of reaction conditions while being removable under mild acidic or fluoride ion conditions, making it ideal for use in sensitive synthetic pathways.
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