(4-iodophenoxy)(tert-butyl)dimethylsilane
90%
Reagent
Code: #119563
CAS Number
133430-99-6
blur_circular Chemical Specifications
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Molecular Information
Weight
334 g/mol
Formula
C₁₂H₁₉IOSi
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Storage & Handling
Storage
room temperature, dry
description Product Description
This compound is the tert-butyldimethylsilyl (TBDMS) ether of 4-iodophenol, serving as a protected intermediate in organic synthesis. The TBDMS group shields the phenolic hydroxyl from unwanted side reactions during multi-step processes, while the para-iodo substituent enables selective functionalization through palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Heck couplings. It is particularly useful in the preparation of complex molecules for pharmaceuticals, natural product analogs, and advanced materials. The protecting group offers good stability under basic and neutral conditions and can be deprotected under acidic conditions when required.
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