Widely used as a source of fluoride ions in organic synthesis, this reagent is particularly effective for desilylation reactions, where it removes silyl protecting groups from alcohols, phenols, and other functional groups under mild conditions. It is favored in peptide and nucleotide chemistry due to its solubility in organic solvents and its ability to operate at room temperature. Also employed in palladium-catalyzed coupling reactions as a base or catalyst activator. Its solution form enhances handling and dosing accuracy compared to anhydrous or solid forms, making it suitable for lab-scale and preparative applications.