Silver citrate is primarily used for its antimicrobial properties in medical and healthcare applications. It is incorporated into wound dressings and burn treatments to prevent infection due to its ability to release silver ions, which are effective against a broad spectrum of bacteria, including antibiotic-resistant strains. Its use in topical formulations helps reduce microbial load without causing significant irritation to tissues.

In addition, silver citrate serves as an active ingredient in some dental materials and oral care products, where it helps control bacterial growth and supports gum health. It is also explored in coatings for medical devices such as catheters to prevent biofilm formation and device-related infections.

Due to its relatively low toxicity and sustained release of silver ions, silver citrate is favored in long-term applications where continuous antimicrobial action is needed without frequent reapplication. Its compatibility with polymers and hydrogels makes it suitable for integration into advanced drug delivery systems and smart responsive materials.