Tetraisopropyl orthosilicate is widely used as a precursor in the production of silica-based materials. It is commonly applied in the synthesis of sol-gel coatings, which are used to create protective layers on various surfaces, including glass, metals, and ceramics. These coatings enhance durability, provide corrosion resistance, and improve optical properties.

In the electronics industry, it serves as a key component in the fabrication of thin films for semiconductors and insulating layers in microelectronic devices. Its ability to form high-purity silica makes it valuable in the manufacturing of optical fibers and waveguides.

Additionally, it is utilized in the production of adhesives, sealants, and binders, where it contributes to improved mechanical strength and thermal stability. In the field of catalysis, it acts as a support material for catalysts, enhancing their efficiency and longevity.

Tetraisopropyl orthosilicate also finds applications in the medical field, particularly in the development of biocompatible coatings for implants and drug delivery systems. Its versatility and effectiveness in forming silica-based structures make it a crucial material in various advanced technologies.