Used as a surface modifier in chromatography, particularly for reverse-phase HPLC columns. It imparts strong hydrophobic characteristics to silica surfaces, enhancing retention of nonpolar compounds. Also applied in the preparation of bonded stationary phases, where its bulky silane structure improves stability and reduces unwanted silanol interactions. Additionally, employed in material science and semiconductor industry to create water-repellent and inert coatings on glass and silicon substrates, reducing moisture absorption and improving stability of electronic devices such as microchips and sensors in humid environments. Used in nanotechnology research to control surface properties like oleophobicity and molecular adhesion.