Isopropoxytrimethylsilane is used as a surface modifier in silica fillers for rubber and tire manufacturing, improving dispersion and reducing viscosity. It enhances adhesion between inorganic fillers and organic polymer matrices in composites. It is employed in coatings and sealants to improve water repellency and durability. It acts as a coupling agent in adhesives, promoting bond strength between dissimilar materials. Additionally, it serves as a mild silylating agent in organic transformations for temporary protection of hydroxyl (-OH) groups, particularly in the synthesis of pharmaceuticals and biomolecules, preventing unwanted reactions and allowing easy deprotection to restore the original -OH functionality. It is also utilized in the synthesis of specialty silanes.