Trimethoxysilane is widely used as a coupling agent in the production of adhesives, sealants, and coatings. It enhances the adhesion between organic polymers and inorganic materials, making it valuable in industries such as construction and automotive manufacturing.

In the field of surface treatment, it is applied to modify glass, metal, and ceramic surfaces, improving their water repellency and durability. This makes it useful for creating protective coatings on building materials and electronic components.

Additionally, trimethoxysilane serves as a precursor in the synthesis of silicone resins and other organosilicon compounds. These materials are utilized in high-performance applications, including heat-resistant coatings and electrical insulation.

Its role in crosslinking polymers also makes it essential in the production of elastomers and composites, providing enhanced mechanical properties and chemical resistance.