Trimethoxymethylsilane is widely used as a coupling agent in the production of composite materials, where it enhances the adhesion between organic polymers and inorganic surfaces. It is particularly effective in improving the mechanical properties and durability of materials like glass-reinforced plastics.

In the coatings industry, it serves as a crosslinking agent, providing water resistance and improved adhesion to substrates such as metals, glass, and ceramics. This makes it valuable in protective coatings for automotive, construction, and marine applications.

Additionally, it is utilized in the synthesis of silicone resins and as a surface modifier for nanoparticles, ensuring better dispersion and stability in various formulations. Its role in silane chemistry also extends to its use as a precursor in the production of specialty chemicals and adhesives.