Chloro(dodecyl)dimethylsilane is widely used as a surface modifier in various industries. It is applied to treat glass, silica, and other inorganic surfaces to make them hydrophobic. This property is particularly useful in the production of water-repellent coatings for construction materials, such as concrete and masonry, enhancing their durability and resistance to moisture.

In the textile industry, it is employed to impart water and oil repellency to fabrics, making them suitable for outdoor and protective clothing. Additionally, it is used in the synthesis of silicone-based polymers and resins, where it acts as a key intermediate to introduce long alkyl chains, improving the flexibility and water resistance of the final products.

In the field of nanotechnology, this compound is utilized to functionalize nanoparticles, enabling their dispersion in non-polar solvents and facilitating their use in advanced materials and coatings. Its ability to modify surfaces at a molecular level makes it a valuable component in the development of high-performance materials with tailored properties.