Halopemide is primarily used in the field of pharmacology as a potent and selective antagonist of the sigma receptors. Its application is significant in research focused on understanding the role of sigma receptors in various neurological and psychiatric disorders. Halopemide has been studied for its potential therapeutic effects in conditions such as schizophrenia, depression, and anxiety, due to its ability to modulate neurotransmitter systems. Additionally, it has been explored for its neuroprotective properties, which could be beneficial in neurodegenerative diseases like Alzheimer's and Parkinson's. The compound is also utilized in preclinical studies to investigate the mechanisms of sigma receptor signaling and its implications in drug addiction and pain management.