S1RA HCl is primarily used in research settings to study the role of sigma-1 receptors in various physiological and pathological processes. It acts as a selective antagonist for sigma-1 receptors, making it a valuable tool for investigating conditions such as neuropathic pain, depression, and neurodegenerative diseases. Researchers utilize it to explore its potential in modulating cellular responses, particularly in the central nervous system. Its application extends to preclinical studies aimed at understanding its therapeutic potential in pain management and psychiatric disorders. Additionally, S1RA HCl is employed in pharmacological experiments to dissect the signaling pathways and mechanisms involving sigma-1 receptors, contributing to the development of novel drug targets.