2-Iodoamphetamine hydrochloride is primarily used in scientific research, particularly in the field of neuroscience and pharmacology. It acts as a selective serotonin releasing agent (SSRA), making it valuable for studying serotonin neurotransmission and its role in various physiological and psychological processes. Researchers utilize this compound to investigate the mechanisms of serotonin release, reuptake, and receptor interactions, which are critical for understanding mood disorders, anxiety, and other serotonin-related conditions. Additionally, it has been employed in radiolabeling studies to trace and visualize serotonin activity in the brain, aiding in the development of diagnostic tools and therapeutic agents targeting the serotonin system.