SDZ281-977 is primarily utilized in research settings for its role as a selective agonist for the 5-HT1A receptor. This receptor is a subtype of serotonin receptors, which play a significant role in regulating mood, anxiety, and other neurological processes. The compound is often employed in studies aimed at understanding the behavioral and physiological effects of 5-HT1A receptor activation. It helps researchers explore potential therapeutic applications for conditions such as depression, anxiety disorders, and other psychiatric illnesses. Additionally, SDZ281-977 is used in pharmacological experiments to investigate the receptor's signaling pathways and its interaction with other neurotransmitter systems. Its specificity makes it a valuable tool in neuroscience and drug development research.