L-690488 is primarily utilized in research settings as a selective and potent antagonist for the 5-HT1D receptor. Its application is significant in the study of serotonin receptor subtypes, particularly in understanding their roles in neurological and psychiatric disorders. Researchers employ L-690488 to investigate the mechanisms underlying conditions such as migraines, anxiety, and depression, as the 5-HT1D receptor is implicated in the modulation of serotonin signaling pathways. Additionally, it is used to explore potential therapeutic targets for these disorders, aiding in the development of more effective pharmacological interventions. Its specificity makes it a valuable tool in elucidating the complex interactions within the serotonin system.