Zatosetron maleate is primarily used in the field of medicine as a potent serotonin receptor antagonist. Its main application is in the prevention and treatment of nausea and vomiting, particularly those induced by chemotherapy in cancer patients. It works by blocking serotonin receptors in the brain and gastrointestinal tract, which are involved in triggering the vomiting reflex. Additionally, it has been studied for its potential use in managing postoperative nausea and vomiting, offering relief to patients recovering from surgical procedures. Its effectiveness and safety profile make it a valuable option in supportive care for patients undergoing treatments that commonly cause severe nausea.