Cuspin-1 is primarily used in research settings as a selective inhibitor of serine proteases, particularly those involved in inflammatory pathways. It shows potential in studying immune responses and regulating excessive protease activity linked to tissue damage. Due to its specificity, Cuspin-1 is employed in biochemical assays to dissect signaling pathways related to inflammation and cell death. It is also explored for its role in modulating host-pathogen interactions, especially in microbial infections where protease activity influences virulence. Its application extends to the development of therapeutic strategies targeting protease-driven diseases, including certain chronic inflammatory conditions and neurodegenerative disorders.