Atipamezole hydrochloride is primarily used as a reversal agent for sedation or anesthesia induced by alpha2-adrenergic agonists such as dexmedetomidine and medetomidine. It is commonly administered in veterinary medicine to rapidly restore consciousness and motor function in animals, especially dogs and laboratory rodents. Its selective antagonism of alpha2-adrenergic receptors allows for quick recovery with minimal side effects. Due to its high efficacy and safety profile, it is widely used in clinical and research settings where controlled sedation is required and prompt reversal is necessary. It can be delivered via intramuscular, intravenous, or subcutaneous routes, making it versatile in emergency and routine procedures.