Ammonium fluoride is widely used in various industrial and laboratory applications. It serves as a key component in the production of glass and ceramics, where it acts as an etching agent to create intricate designs or smooth surfaces. In the electronics industry, it is utilized for cleaning and etching silicon wafers during the manufacturing of semiconductors. Additionally, it is employed in wood preservation treatments to protect against fungal decay and insect damage. In analytical chemistry, it is used as a buffering agent and in the preparation of fluoride-containing solutions, such as for quantifying silica in samples. Its ability to react with metal oxides also makes it useful in metal surface treatment and cleaning processes. It can also serve as an additive in coatings to enhance corrosion resistance.

Caution is advised when handling ammonium fluoride, as it can be hazardous to health and the environment if not used properly.