Used as an anti-reflective coating in optical devices such as lenses, solar panels, cameras, microscopes, and eyeglasses due to its low refractive index and high transparency in the ultraviolet to infrared range. Commonly applied in thin-film form through vacuum deposition to enhance light transmission and reduce glare, resulting in sharper images.

Also serves as a durable window material in infrared spectroscopy, thermal imaging systems, lighting, and laser applications because of its resistance to harsh environments, including UV radiation. Employed in some laser systems as a component in prisms and mirrors.

In the semiconductor industry, magnesium fluoride is used as an insulating material and to control high-precision processes in electronic component manufacturing.

Additionally, used in the production of certain types of glass and ceramics to improve thermal and chemical stability, as well as in materials science research for durable coatings.