Calcium bromide solution is widely used in the oil and gas industry as a completion and workover fluid in drilling operations. Its high density helps control wellbore pressure, preventing blowouts during production and maintenance. The solution is particularly valued in deep wells where stable, heavy fluids are required.

It is also used in the chemical synthesis of other bromide compounds, serving as a source of bromide ions in aqueous reactions. In some cases, it functions as a desiccant or drying agent due to its hygroscopic nature, useful in controlling moisture in industrial processes.

Additionally, calcium bromide solution finds application in water treatment and as a flux in the textile and dyeing industries, improving process efficiency. Its ability to enhance solubility and stability in certain formulations makes it suitable for use in specialty cleaning agents and corrosion inhibitors.