Calcium fluoride is widely used in the metallurgical industry as a flux in the smelting of aluminum and steel, helping to lower the melting point of raw materials and remove impurities. It plays a key role in the production of hydrofluoric acid, which is essential for manufacturing refrigerants and fluoropolymers.

In the optical industry, high-purity calcium fluoride is used to make lenses and windows for ultraviolet and infrared spectrometers due to its excellent transparency over a wide spectral range.

It is also used in the manufacture of specialty glasses and enamels, where it improves durability and resistance to thermal shock.

Additionally, calcium fluoride serves as a source of fluoride in some industrial processes and is used in certain types of welding rod coatings to stabilize the arc and improve weld quality.