Grela 1st Generation catalysts are widely used in olefin metathesis reactions, a key process in organic synthesis. These catalysts are particularly effective in ring-closing metathesis, enabling the formation of cyclic compounds with high efficiency and selectivity. They are also employed in cross metathesis reactions, which are essential for creating carbon-carbon bonds between different olefins. Additionally, Grela 1st Generation catalysts are utilized in the synthesis of complex natural products and pharmaceuticals, where their stability and reactivity under mild conditions are advantageous. Their application extends to polymer chemistry, where they facilitate the production of advanced materials with tailored properties. Overall, these catalysts are valued for their versatility and performance in various synthetic transformations.