SB-772077B dihydrochloride is a potent and selective inhibitor of Rho-associated protein kinase (ROCK). It is primarily utilized in research settings to study its effects on vascular smooth muscle relaxation and cardiovascular pathways. This makes it valuable for understanding mechanisms of hypertension, vasospasm, and related cardiovascular disorders, as well as potential applications in metabolic conditions influenced by vascular function. Researchers employ it in preclinical studies to evaluate efficacy and safety in animal models, and in biochemical assays to explore interactions with target proteins, aiding in the design of novel drugs. Its use is confined to laboratory environments, advancing pharmacology and biomedical science.