TMRE is widely used in research to assess mitochondrial membrane potential in living cells. It is a fluorescent dye that accumulates in active mitochondria, making it a valuable tool for studying mitochondrial function and health. Researchers often use TMRE in studies related to apoptosis, as changes in mitochondrial membrane potential are early indicators of programmed cell death. It is also employed in neurobiology to investigate mitochondrial activity in neurons, which is crucial for understanding cellular energy metabolism and neurodegenerative diseases. Additionally, TMRE is used in cancer research to evaluate the metabolic state of cancer cells and their response to therapeutic agents. Its ability to provide real-time, quantitative data makes it a key reagent in cellular and molecular biology studies.