Iberiotoxin trifluoroacetate salt is primarily used in research applications to study ion channels, particularly large-conductance calcium-activated potassium (BK) channels. It acts as a potent and selective blocker of these channels, making it a valuable tool for understanding their physiological roles in various tissues, including smooth muscle, neurons, and secretory cells. In neuroscience, it helps investigate the regulation of neuronal excitability and neurotransmitter release. In cardiovascular research, it aids in studying vascular tone and blood pressure regulation. Additionally, it is utilized in pharmacological studies to explore potential therapeutic targets for conditions like hypertension, epilepsy, and other disorders linked to BK channel dysfunction. Its high specificity ensures minimal interference with other ion channels, enhancing the accuracy of experimental results.