LSKL is primarily used in research to inhibit the activity of thrombospondin-1 (TSP-1), a protein involved in various cellular processes. By blocking TSP-1, LSKL helps study its role in angiogenesis, cancer progression, and tissue repair. It is particularly valuable in understanding how TSP-1 influences TGF-β activation, which is critical in fibrosis and immune regulation. Researchers also use LSKL to explore its potential therapeutic applications in conditions like wound healing, tumor growth, and inflammatory diseases. Its ability to modulate TSP-1 interactions makes it a key tool in biomedical studies.