Cyclo(his-pro), also known as Cyclo(histidyl-proline) or histidylproline diketopiperazine, is a cyclic dipeptide widely studied for its potential therapeutic and cosmetic applications. In neuroscience and endocrinology, it modulates the release of key neurotransmitters, positioning it as a candidate for treating neurological disorders such as Alzheimer's and Parkinson's disease. It also regulates insulin secretion, showing promise for managing diabetes and metabolic conditions. The compound exhibits anti-inflammatory and antioxidant properties, aiding in neuroprotection, reducing oxidative stress, and improving cognitive function.

Additionally, in dermatology and cosmetics, Cyclo(his-pro) is used in skincare products to delay wrinkle formation, enhance skin elasticity, and stimulate collagen and elastin production, thanks to its antioxidant effects that protect cells from oxidative damage.

Ongoing research explores its broader efficacy in balancing the nervous system, reducing stress, and controlling blood sugar levels, highlighting its versatility in medical, pharmacological, and cosmetic fields.