Tat-NR2B9c TFA is primarily used in neuroscience research to study the mechanisms of synaptic plasticity and memory formation. It functions as a potent inhibitor of the interaction between the NMDA receptor subunit NR2B and the postsynaptic density protein PSD-95, which is crucial for regulating excitatory synaptic transmission. By disrupting this interaction, it helps researchers investigate the role of NMDA receptors in learning, memory, and neurodegenerative diseases such as Alzheimer's. Additionally, it is utilized in experimental models to explore potential therapeutic strategies for stroke and other conditions involving excitotoxicity. Its cell-penetrating Tat peptide sequence allows for efficient delivery into neurons, making it a valuable tool for in vitro and in vivo studies.