Used in research and development of therapies targeting the TrkB receptor, which is involved in neurodevelopment, neurodegenerative diseases, and certain cancers. This antibody serves as a reference tool for characterizing TrkB signaling, evaluating drug candidates, and assessing target engagement in preclinical studies. It is also utilized in immunoassays and binding studies to measure TrkB expression and inhibition. Due to its well-characterized properties, it supports the development of biologics and small molecules aimed at modulating TrkB activity in conditions such as Alzheimer’s disease, depression, and tumors with NTRK2 alterations.