Used in immunological research to study the role of TREM1 (Triggering Receptor Expressed on Myeloid cells 1) in inflammatory responses. This reference antibody (PY159) helps detect and modulate TREM1 activity, including inhibition of TREM1 signaling to reduce excessive immune responses and tissue damage in conditions like infections, sepsis, and autoimmune diseases.

It serves as a tool for validating assays, including Western blot, flow cytometry, and immunohistochemistry (IHC), to analyze TREM1 expression on myeloid cells such as monocytes and neutrophils in preclinical and clinical settings.

Additionally, it acts as a benchmark for developing therapeutic antibodies targeting the TREM1 pathway, potentially reducing pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, for applications in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and pneumonia, with potential in diagnostics and drug development.